发布日期：2025-01-03 18:02 点击次数：169
徐颖洁 研究员
联系方式：上海市重庆南路280号上海交通大学医学院
E-mail： [email protected]
实验室人员组成：
PI：徐颖洁
助理研究员：于翔
技术员：殷亚男
博士后：黄玛莎
研究生：张佳慧，安之音，张宇，曾洁
联合培养：夏佳
课题组长主要学习工作经历：
上海第二医科大学临床医学七年制，获医学硕士学位
加拿大麦吉尔大学实验医学系，获博士学位
美国哈佛医学院波士顿儿童医院，博士后
研究方向与进展：
1、 介导癌症转移及耐药的分子靶点发现、机制探究和靶向治疗评估
2、 优化mRNA的体外合成与体内递送
3、 研发基于mRNA的治疗应用：包括癌症mRNA疫苗、感染性疾病mRNA疫苗、mRNA的蛋白替代疗法在癌症及其他疾病中的应用
代表论文：
1. Zhang J, Li Y, Liu H, Zhang J,Wang J, Xia J, Zhang Y, Yu X, Ma J, Huang M, Wang J, Wang L, Li Q, Cui R, Yang W*, Xu Y*，Feng W*. Genome-wide CRISPR/Cas9 library screen identifies PCMT1 as a critical driver of ovarian cancer metastasis. J Exp Clin Cancer Res. 2022; 41:24. doi: 10.1186/s13046-022-02242-3(* Co-correspoding author)
2. Xia, J., Zhang, J., Wang, L., Xu, Y., Yang, W., Yu, Y.(2021). Non-apoptotic function of caspase-8 confers prostate cancer enzalutamide resistance via NF-κB activation. Cell Death Disease 12,833.
3. Zhang, JH; Yin, YN; Wang, JH; Zhang, JJ; Liu, H; Feng, WW; Yang, W; Bruce Zetter; Xu, YJ.(2021).Prohibitin regulates mTOR pathway via the interaction with FKBP8. Frontiers of Medicine 15,448-459
4.杭辰悦,徐山杉,吴其峰,张普昱,张宇,徐颖洁. mRNA 治疗及其应用前景.(2021).科学通报, Z2期
5.Lu,J;Lu,GL; Tan,SD; Xia, J; Xiong, HL;Yu, XF; Qi, QQ; Yu,X; Li, L; Yu, H; Xia, NS; Zhang, TY*, Xu, YJ*; Lin, JZ*.(2020). A COVID-19 mRNA vaccine encoding SARS-CoV-2 virus-like particles induces a strong antiviral-like immune response in mice.Cell Research 10 ,936-939.(*Co-corresponding author)
6.Islam MA, Xu Y*, Tao W, et al. Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA. Nature Biomedical Engineering. 2018 Nov;2(11):850-864. DOI: 10.1038/s41551-018-0284-0. PMID: 31015614; PMCID: PMC6486184.(*Co-first author)
7.Xu Y, Yang W, Shi J, Zetter BR. Prohibitin 1 regulates tumor cell apoptosis via interaction with X-linked Inhibitor of Apoptosis Protein. J Mol Cell Biol. 2016 Jun; 8(3):282-5. doi: 10.1093/jmcb/mjw018.
8.Zhu X, Xu Y*, Solis LM, Tao W, Wang L, Behrens C, Xu X, Zhao L, Liu D, Wu J, Zhang N, Wistuba II, Farokhzad OC, Zetter BR, Shi J. Long-circulating siRNA nanoparticles for validating Prohibitin1-targeted non-small cell lung cancer treatment. Proc Natl Acad Sci U S A. 2015 Jun 23; 112(25):7779-84. (*Co-first author)
9.Shi J, Xu Y*, Xu X, Zhu X, Pridgen E, Wu J, Alexander V, Zetter BR, Farokhzad O. Hybrid Lipid-Polymer Nanoparticles for Sustained siRNA Delivery and Gene Silencing. Nanomedicine. 2014 Jul; 10(5):897-900. doi: 10.1016/j.nano.2014.03.006. (*Co-first author)
10.Xu Y, Bismar TA, Su J, Xu B, Kristiansen G, Varga Z, Teng L, Ingber DE, Mammoto A, Kumar R, Alaoui-Jamali MA. Filamin A regulates focal adhesion disassembly and suppresses breast cancer cell migration and invasion. J Exp Med. 2010 Oct 25; 207(11):2421-37. Epub 2010 Oct 11.
